7. An eye-opener on double-blind studies
The core of present-day scientific medicine is more and more boiling down to ‘evidence based medicine’ (EBM). The essence of EBM is double-blind studies: comparing a new supposedly-active substance to placebo whereby both prescriber(s) and patients are ignorant (‘blind’) in regard to whether they get placebo or the ‘active’ substance.
◊◊◊
Nice.
◊◊◊
Everything (really: everything in this matter) stands or falls with whether blind is blind. If it is, then so much the better. If it isn’t, then present-day scientific medicine is still at a low level of science and should evolve from this with extreme urgency.
◊◊◊
So: is blind very blind? I don’t think so.
◊◊◊
The point is that a placebo doesn’t work through conscious expectation. As a matter of fact, it doesn’t work through a conscious whatsoever. If a placebo for instance lowers the blood pressure, it’s not because you consciously lower your BP. Purely consciously, you’re not capable of doing so. Placebo (or better said: your own inner strength in this) works through the subconscious. Therefore the subconscious is what is important in all this.
◊◊◊
So the pertinent question is not whether you are consciously blind, but rather whether you are subconsciously blind. That is a question that has hardly at all entered into scientifically.
◊◊◊
Take the side effects of medication. Does the subconscious register consciously-felt side effects? To me there is no doubt about this. Can it also register not-consciously-felt side effects? Let me ask it like this: why shouldn’t it? One can be certain that the subconscious registers any bodily change. Therefore also the slightest side-effect of medication.
◊◊◊
Since medication (the ‘active substance’ in double-blind studies) always has lots of side effects, while a pure placebo has as good as none, to the subconscious at least the difference is always clear. This is: at this very important level, there is little or no double-blindness at all. Let me repeat this.
◊◊◊
There is little or no double-blindness at all!
◊◊◊
The same argument can be made not only for the side-effects, but also for the meant effect. This makes it even worse!
◊◊◊
Conclusion: a double-blind study compares an active substance, potentially having lots of placebo-activity, to a placebo with relatively little placebo-activity. While such a study is supposed to lead to a subtraction of placebo-activity, quite the reverse happens in reality. Scientists are beginning to become aware of this problem. All too slowly.
◊◊◊
As said, this is the essence of the core of present-day scientific medicine.
◊◊◊
Related Posts
Why We Need Serial Treatment Assumption Testing
In medicine – regular and alternative (CAM) – Serial Treatment Assumption Testing (STAT) is a feasible and necessary tool to open up what has always been medical science’s intention. What is STAT? Quite straightforwardly, in its essence, it’s about serially asking study subjects to guess in which of two study groups they are (active medication Read the full article…
The Disease and the Reality
Disease differentiates the healthy from the diseased. Reality is much fuzzier. Continua In another blog text, I described diseases as – at least in many cases – continua rather than binary entities. [see: “A Disease is a Continuum, Not an Entity“] There is also a continuum from healthy to ‘diseased.’ I also wrote about disease Read the full article…
Lisa Anesthesia
Imagine a surgical environment where patients experience minimal use of traditional anesthesia, instead receiving personalized, calming support from advanced technology. This is the vision of Lisa Anesthesia, an innovative approach that combines minimal anesthetic assistance with A.I.-guided autosuggestion to optimize patient comfort and recovery. ― Coming up soon. What is Lisa Anesthesia? Lisa Anesthesia is Read the full article…